Dr. Bethel studied under Michael Grabe at UCSF as a biophysics PhD student. Using computational techniques such as molecular dynamics, enhanced sampling, and numerical integration, he investigated membrane remodelling transmembrane proteins. As an HHMI Hanna Gray Postdoctoral Fellow and under the mentorship of David Baker at the Institute of Protein Design, he utilized deep learning, Rosetta and electron microscopy to design and validate a new family of highly modular protein oligomers. The Bethel lab builds on many of these approaches to investigate protein conformational change, allostery and to build new molecular switches for cell biology applications